Jennifer Stone When the oil is utilised as a suppository does it show up in drug tests if the oil is not heated?
Suppositories may be used vaginally OR rectally with an identical take-up in the bloodstream. For any condition affecting organs below the lungs please use suppositories and oral ingestion. For any conditions above the lungs oral ingestion and vaporising oil has proven the most effective means of delivering cannabinoids.
The administration of Cannabis oil in a suppository base can be more beneficial in the bioavailability (Fraction of a dose of drug that is absorbed from its site of administration and reaches, in an unchanged form, the systemic circulation) By delivering straight into systemic via rectal route you bypass destruction of cannabis oil by stomach acid. The development of new formulations of suppositories has resulted in improved absorption and bioavailability of β -lactams and aminoglycosides. The enhancing effect of Witepsol H15 (saturated triglycerides), a saturated straight-chain fatty acids on the rectal absorption has been proven in animal experiments.http://www.google.com/patents/EP0752838B1?cl=en Witepsol H15 has been proven to deliver most effectively because drug absorption in the rectum Although the rectum has a good blood supply, it is devoid of villi and has relatively small surface area.The mechanisms of rectal absorption of drugs are not significantly different from those in the upper part of the gastrointestinal tract. Some have concluded that, after rectal administration, passive transport is the main mechanism of absorption, that the absorption is mainly dependent on the molecular weight, liposolubility and degree of ionization of molecules, and that basic drugs are absorbed faster in the presence of anions like sodium lauryl sulphate. Depending on their chemical structure, drugs may cross the rectal wall either by absorption across the epithelial cell (transcellular) or via the tight junctions interconnecting the mucosal cells (paracellular). Several local host factors may influence absorption in the rectum: the mucous layer, the variable volume of rectal fluid, the basal cell membrane, the tight junctions and the intracellular compartments may each constitute local barriers to drug absorption, depending on histological factors and on the molecular structure of the administered drug. The pharmaceutical formulation, therefore, may play a major role in the rectal absorption and consequently in the systemic distribution and pharmacokinetics of cannabis oil administered via suppository.While Δ9-THC itself is not absorbed through the rectal route, the pro-drug Δ9-THC-hemisuccinate(witepsol H15) is absorbed; this fact, combined with decreased first-pass metabolism through the rectal route, results in a higher bioavailability of Δ9-THC by the rectal route (52 - 61%). Plasma concentrations of Δ9-THC are dose and vehicle-dependent, and also vary according to the chemical structure of the THC ester. In humans, rectal doses of 2.5 - 5.0 mg of the hemisuccinate ester of Δ9-THC were associated with peak plasma levels of Δ9-THC ranging between 1.1 and 4.1 ng/mL within 2 - 8 h, and peak plasma levels of carboxy-Δ9-THC ranging between 6.1 - 42.0 ng/mL within 1 - 8 h after administration. This research is using the ester Witepsol H15. Now Cocoa butter also has a great vehicle benefit because it is a polyphenol.http://www.ncbi.nlm.nih.gov/pubmed/11682694 But it is insoluble in water and in the rectums anatomy :
- The rectum is part of the colon,
forming the last 15 – 20 cm of the GI tract.
- The rectum can be considered as a hollow
organ with a relatively flat wall surface, without
villi.
- It contains only 2 – 3 ml of inert mucous fluid
with pH of 7.5 The quantity of fluid available for drug dissolution is
very small (approximately 3 ml). Thus the dissolution
of slightly soluble substances is the slowest step in
the absorptive process.https://uqu.edu.sa/.../files/4290121/SUPPOSITORIES.pdf
Suppositories may be used vaginally OR rectally with an identical take-up in the bloodstream. For any condition affecting organs below the lungs please use suppositories and oral ingestion. For any conditions above the lungs oral ingestion and vaporising oil has proven the most effective means of delivering cannabinoids.
The administration of Cannabis oil in a suppository base can be more beneficial in the bioavailability (Fraction of a dose of drug that is absorbed from its site of administration and reaches, in an unchanged form, the systemic circulation) By delivering straight into systemic via rectal route you bypass destruction of cannabis oil by stomach acid. The development of new formulations of suppositories has resulted in improved absorption and bioavailability of β -lactams and aminoglycosides. The enhancing effect of Witepsol H15 (saturated triglycerides), a saturated straight-chain fatty acids on the rectal absorption has been proven in animal experiments.http://www.google.com/patents/EP0752838B1?cl=en Witepsol H15 has been proven to deliver most effectively because drug absorption in the rectum Although the rectum has a good blood supply, it is devoid of villi and has relatively small surface area.The mechanisms of rectal absorption of drugs are not significantly different from those in the upper part of the gastrointestinal tract. Some have concluded that, after rectal administration, passive transport is the main mechanism of absorption, that the absorption is mainly dependent on the molecular weight, liposolubility and degree of ionization of molecules, and that basic drugs are absorbed faster in the presence of anions like sodium lauryl sulphate. Depending on their chemical structure, drugs may cross the rectal wall either by absorption across the epithelial cell (transcellular) or via the tight junctions interconnecting the mucosal cells (paracellular). Several local host factors may influence absorption in the rectum: the mucous layer, the variable volume of rectal fluid, the basal cell membrane, the tight junctions and the intracellular compartments may each constitute local barriers to drug absorption, depending on histological factors and on the molecular structure of the administered drug. The pharmaceutical formulation, therefore, may play a major role in the rectal absorption and consequently in the systemic distribution and pharmacokinetics of cannabis oil administered via suppository.While Δ9-THC itself is not absorbed through the rectal route, the pro-drug Δ9-THC-hemisuccinate(witepsol H15) is absorbed; this fact, combined with decreased first-pass metabolism through the rectal route, results in a higher bioavailability of Δ9-THC by the rectal route (52 - 61%). Plasma concentrations of Δ9-THC are dose and vehicle-dependent, and also vary according to the chemical structure of the THC ester. In humans, rectal doses of 2.5 - 5.0 mg of the hemisuccinate ester of Δ9-THC were associated with peak plasma levels of Δ9-THC ranging between 1.1 and 4.1 ng/mL within 2 - 8 h, and peak plasma levels of carboxy-Δ9-THC ranging between 6.1 - 42.0 ng/mL within 1 - 8 h after administration. This research is using the ester Witepsol H15. Now Cocoa butter also has a great vehicle benefit because it is a polyphenol.http://www.ncbi.nlm.nih.gov/pubmed/11682694 But it is insoluble in water and in the rectums anatomy :
- The rectum is part of the colon,
forming the last 15 – 20 cm of the GI tract.
- The rectum can be considered as a hollow
organ with a relatively flat wall surface, without
villi.
- It contains only 2 – 3 ml of inert mucous fluid
with pH of 7.5 The quantity of fluid available for drug dissolution is
very small (approximately 3 ml). Thus the dissolution
of slightly soluble substances is the slowest step in
the absorptive process.https://uqu.edu.sa/.../files/4290121/SUPPOSITORIES.pdf
No comments:
Post a Comment