DIPG, Prostate Cancer
Cabazitaxel is used in Prostrate Cancer and I am not sure what 'Off the Label' Protocols are directed towards using this in DIPG...http://en.wikipedia.org/wiki/Cabazitaxel
just checked and it looks like it does actually have validity in glioblastoma. From the Authors: Cabazitaxel penetrated rapidly in the brain, with a similar brain–blood radioactivity exposure relationship across different animal species. In intracranial human glioblastoma models, cabazitaxel demonstrated superior activity to docetaxel both at early (before BBB disruption) and at advanced stages, consistent with enhanced brain penetration.
Compared with similar dose levels of docetaxel, cabazitaxel induced significantly greater tumor growth inhibition across six pediatric tumor models and more tumor regressions in five of the six models. Therapeutic synergism was observed between cisplatin and cabazitaxel, regardless of administration sequence.http://link.springer.com/article/10.1007/s00280-013-2214-x
Cabazitaxel is used in Prostrate Cancer and I am not sure what 'Off the Label' Protocols are directed towards using this in DIPG...http://en.wikipedia.org/wiki/Cabazitaxel
just checked and it looks like it does actually have validity in glioblastoma. From the Authors: Cabazitaxel penetrated rapidly in the brain, with a similar brain–blood radioactivity exposure relationship across different animal species. In intracranial human glioblastoma models, cabazitaxel demonstrated superior activity to docetaxel both at early (before BBB disruption) and at advanced stages, consistent with enhanced brain penetration.
Compared with similar dose levels of docetaxel, cabazitaxel induced significantly greater tumor growth inhibition across six pediatric tumor models and more tumor regressions in five of the six models. Therapeutic synergism was observed between cisplatin and cabazitaxel, regardless of administration sequence.http://link.springer.com/article/10.1007/s00280-013-2214-x
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