Alternative Medical Institute

Thursday, 1 January 2015

Cannabis kills cancer cells 121 studies. THC and CBD

Flavonoids Best Sources - Well Being

Bruce Cox shared Dan Molecule's photo.

2 hrs ·

Dan Molecule

SO WHAT IS A FLAVONOID YOU ASK HERE IS SOME INFO:

*It's important to note that in the U.S. the largest single source of flavonoids is black and green tea, and that over half of all flavonoid intake comes from the flavan-3-ol subgroup that is so concentrated in tea; this subgroup includes catechins, epicatechins, gallocatechins, and theaflavins.

As you can see, it takes a variety of foods from a variety of different food groups to give you a good cross-section of flavonoid subcategories. The USDA estimates that in the U.S., daily total flavonoid consumption by the average adult is approximately 250-275 milligrams, with about half of total consumption coming in the form of flavan-3-ols from black and green tea.

The colorful reds, blues, and purples in berries are provided by their anthocyanidins, and that is why you find so many of these fruits listed in the anthocyanidin column.

As a group of phytonutrients, flavonoids emphasize—in a way that is not as well emphasized by perhaps any other nutrient—how valuable fruits and vegetables are to our nourishment and everyday health. since flavonoids are water-soluble, we would expect them to follow a pattern associated with other water-soluble nutrients. That pattern involves lower risk of toxicity than is associated with fat-soluble nutrients, and in many cases, a decision by the National Academy of Sciences (NAS) not to establish a Tolerable Upper Intake Level (UL) for water-soluble vitamins like vitamin B1 or vitamin B2 when obtained from food. We suspect that a similar decision might end up holding true for flavonoids as well, although it's important to remember that the NAS has yet to even establish flavonoids as a required human nutrient or to set Dietary Reference Intake (DRI) amounts for flavonoids as a group or for any specific flavonoid.

There are no specific public health recommendations for flavonoid intake. There are currently no Dietary Reference Intakes (DRIs) from the National Academy of Sciences and there is no Daily Value (DV) from the U.S. Food and Drug Administration. However, as described earlier in our Risk of Dietary Toxicity section, our recommendation for optimal flavonoid intake is to focus on a whole, natural, fresh foods diet that provides ample servings of vegetables and fruits. In many of our sample daily meal plans, the total vegetable-plus-fruit servings add up to 5-8 servings or more. When coupled with other flavonoid-rich foods—including nuts, seeds, beans, legumes, and whole grains—your flavonoid intake is likely to far surpass the current U.S. average level of approximately 250-275 milligrams, and may in fact get closer to a level of approaching 1 gram (1,000 milligrams).

Disease Checklist

Easy bruising
Skin damage from sun
Hay fever
Prostatitis
Osteoarthritis
Rheumatoid arthritis
Hot flashes
Venous insufficiency
Cardiovascular disease (prevention)
Low immune function
COPD (Chronic Obstructive Pulmonary Disease)

Wednesday, 31 December 2014

Cannabis oil and gliomas

Here's an interesting discussion about hash/cannabis oil- It's long, so you might want to read the conclusion first.
http://www.sciencebasedmedicine.org/hash-oil-for-gliomas.../
Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3–dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis. We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo. These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673842/?tool=pmcentrez

Cannabis oil how to be taken?

Jennifer Stone When the oil is utilised as a suppository does it show up in drug tests if the oil is not heated?
Suppositories may be used vaginally OR rectally with an identical take-up in the bloodstream. For any condition affecting organs below the lungs please use suppositories and oral ingestion. For any conditions above the lungs oral ingestion and vaporising oil has proven the most effective means of delivering cannabinoids.
The administration of Cannabis oil in a suppository base can be more beneficial in the bioavailability (Fraction of a dose of drug that is absorbed from its site of administration and reaches, in an unchanged form, the systemic circulation) By delivering straight into systemic via rectal route you bypass destruction of cannabis oil by stomach acid. The development of new formulations of suppositories has resulted in improved absorption and bioavailability of β -lactams and aminoglycosides. The enhancing effect of Witepsol H15 (saturated triglycerides), a saturated straight-chain fatty acids on the rectal absorption has been proven in animal experiments.http://www.google.com/patents/EP0752838B1?cl=en Witepsol H15 has been proven to deliver most effectively because drug absorption in the rectum Although the rectum has a good blood supply, it is devoid of villi and has relatively small surface area.The mechanisms of rectal absorption of drugs are not significantly different from those in the upper part of the gastrointestinal tract. Some have concluded that, after rectal administration, passive transport is the main mechanism of absorption, that the absorption is mainly dependent on the molecular weight, liposolubility and degree of ionization of molecules, and that basic drugs are absorbed faster in the presence of anions like sodium lauryl sulphate. Depending on their chemical structure, drugs may cross the rectal wall either by absorption across the epithelial cell (transcellular) or via the tight junctions interconnecting the mucosal cells (paracellular). Several local host factors may influence absorption in the rectum: the mucous layer, the variable volume of rectal fluid, the basal cell membrane, the tight junctions and the intracellular compartments may each constitute local barriers to drug absorption, depending on histological factors and on the molecular structure of the administered drug. The pharmaceutical formulation, therefore, may play a major role in the rectal absorption and consequently in the systemic distribution and pharmacokinetics of cannabis oil administered via suppository.While Δ9-THC itself is not absorbed through the rectal route, the pro-drug Δ9-THC-hemisuccinate(witepsol H15) is absorbed; this fact, combined with decreased first-pass metabolism through the rectal route, results in a higher bioavailability of Δ9-THC by the rectal route (52 - 61%). Plasma concentrations of Δ9-THC are dose and vehicle-dependent, and also vary according to the chemical structure of the THC ester. In humans, rectal doses of 2.5 - 5.0 mg of the hemisuccinate ester of Δ9-THC were associated with peak plasma levels of Δ9-THC ranging between 1.1 and 4.1 ng/mL within 2 - 8 h, and peak plasma levels of carboxy-Δ9-THC ranging between 6.1 - 42.0 ng/mL within 1 - 8 h after administration. This research is using the ester Witepsol H15. Now Cocoa butter also has a great vehicle benefit because it is a polyphenol.http://www.ncbi.nlm.nih.gov/pubmed/11682694 But it is insoluble in water and in the rectums anatomy :
- The rectum is part of the colon,
forming the last 15 – 20 cm of the GI tract.
- The rectum can be considered as a hollow
organ with a relatively flat wall surface, without
villi.
- It contains only 2 – 3 ml of inert mucous fluid
with pH of 7.5 The quantity of fluid available for drug dissolution is
very small (approximately 3 ml). Thus the dissolution
of slightly soluble substances is the slowest step in
the absorptive process.https://uqu.edu.sa/.../files/4290121/SUPPOSITORIES.pdf

Patent EP0752838B1 - Stable suppository formulations of delta-9-thc...

GOOGLE.COM

Tuesday, 30 December 2014

Final Report, The use of Cannabis for medical purposes -NSW Parliament

http://www.parliament.nsw.gov.au/.../FDB7842246A5AB71CA25...

Final Report, The use of cannabis for medical purposes - NSW Parliament

15/05/2013: Final Report, Use of cannabis for medical...

PARLIAMENT.NSW.GOV.AU

Cabazitaxel

DIPG, Prostate Cancer

Cabazitaxel is used in Prostrate Cancer and I am not sure what 'Off the Label' Protocols are directed towards using this in DIPG...http://en.wikipedia.org/wiki/Cabazitaxel

just checked and it looks like it does actually have validity in glioblastoma. From the Authors: Cabazitaxel penetrated rapidly in the brain, with a similar brain–blood radioactivity exposure relationship across different animal species. In intracranial human glioblastoma models, cabazitaxel demonstrated superior activity to docetaxel both at early (before BBB disruption) and at advanced stages, consistent with enhanced brain penetration.
Compared with similar dose levels of docetaxel, cabazitaxel induced significantly greater tumor growth inhibition across six pediatric tumor models and more tumor regressions in five of the six models. Therapeutic synergism was observed between cisplatin and cabazitaxel, regardless of administration sequence.http://link.springer.com/article/10.1007/s00280-013-2214-x

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