Cannabis oil and gliomas

 Here's an interesting discussion about hash/cannabis oil- It's long, so you might want to read the conclusion first. 
http://www.sciencebasedmedicine.org/hash-oil-for-gliomas.../
Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3–dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis. We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo. These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673842/?tool=pmcentrez

Cannabis oil how to be taken?

Jennifer Stone When the oil is utilised as a suppository does it show up in drug tests if the oil is not heated?
Suppositories may be used vaginally OR rectally with an identical take-up in the bloodstream. For any condition affecting organs below the lungs please use suppositories and oral ingestion. For any conditions above the lungs oral ingestion and vaporising oil has proven the most effective means of delivering cannabinoids.
The administration of Cannabis oil in a suppository base can be more beneficial in the bioavailability (Fraction of a dose of drug that is absorbed from its site of administration and reaches, in an unchanged form, the systemic circulation) By delivering straight into systemic via rectal route you bypass destruction of cannabis oil by stomach acid. The development of new formulations of suppositories has resulted in improved absorption and bioavailability of β -lactams and aminoglycosides. The enhancing effect of Witepsol H15 (saturated triglycerides), a saturated straight-chain fatty acids on the rectal absorption has been proven in animal experiments.http://www.google.com/patents/EP0752838B1?cl=en Witepsol H15 has been proven to deliver most effectively because drug absorption in the rectum Although the rectum has a good blood supply, it is devoid of villi and has relatively small surface area.The mechanisms of rectal absorption of drugs are not significantly different from those in the upper part of the gastrointestinal tract. Some have concluded that, after rectal administration, passive transport is the main mechanism of absorption, that the absorption is mainly dependent on the molecular weight, liposolubility and degree of ionization of molecules, and that basic drugs are absorbed faster in the presence of anions like sodium lauryl sulphate. Depending on their chemical structure, drugs may cross the rectal wall either by absorption across the epithelial cell (transcellular) or via the tight junctions interconnecting the mucosal cells (paracellular). Several local host factors may influence absorption in the rectum: the mucous layer, the variable volume of rectal fluid, the basal cell membrane, the tight junctions and the intracellular compartments may each constitute local barriers to drug absorption, depending on histological factors and on the molecular structure of the administered drug. The pharmaceutical formulation, therefore, may play a major role in the rectal absorption and consequently in the systemic distribution and pharmacokinetics of cannabis oil administered via suppository.While Δ9-THC itself is not absorbed through the rectal route, the pro-drug Δ9-THC-hemisuccinate(witepsol H15) is absorbed; this fact, combined with decreased first-pass metabolism through the rectal route, results in a higher bioavailability of Δ9-THC by the rectal route (52 - 61%). Plasma concentrations of Δ9-THC are dose and vehicle-dependent, and also vary according to the chemical structure of the THC ester. In humans, rectal doses of 2.5 - 5.0 mg of the hemisuccinate ester of Δ9-THC were associated with peak plasma levels of Δ9-THC ranging between 1.1 and 4.1 ng/mL within 2 - 8 h, and peak plasma levels of carboxy-Δ9-THC ranging between 6.1 - 42.0 ng/mL within 1 - 8 h after administration. This research is using the ester Witepsol H15. Now Cocoa butter also has a great vehicle benefit because it is a polyphenol.http://www.ncbi.nlm.nih.gov/pubmed/11682694 But it is insoluble in water and in the rectums anatomy :
- The rectum is part of the colon, 
forming the last 15 – 20 cm of the GI tract.
- The rectum can be considered as a hollow 
organ with a relatively flat wall surface, without 
villi.
- It contains only 2 – 3 ml of inert mucous fluid
with pH of 7.5 The quantity of fluid available for drug dissolution is
very small (approximately 3 ml). Thus the dissolution
of slightly soluble substances is the slowest step in
the absorptive process.https://uqu.edu.sa/.../files/4290121/SUPPOSITORIES.pdf

Patent EP0752838B1 - Stable suppository formulations of delta-9-thc...

GOOGLE.COM

Final Report, The use of Cannabis for medical purposes -NSW Parliament

http://www.parliament.nsw.gov.au/.../FDB7842246A5AB71CA25...

Final Report, The use of cannabis for medical purposes - NSW Parliament

15/05/2013: Final Report, Use of cannabis for medical...

PARLIAMENT.NSW.GOV.AU

Cabazitaxel

DIPG, Prostate Cancer


 Cabazitaxel is used in Prostrate Cancer and I am not sure what 'Off the Label' Protocols are directed towards using this in DIPG...http://en.wikipedia.org/wiki/Cabazitaxel

 just checked and it looks like it does actually have validity in glioblastoma. From the Authors: Cabazitaxel penetrated rapidly in the brain, with a similar brain–blood radioactivity exposure relationship across different animal species. In intracranial human glioblastoma models, cabazitaxel demonstrated superior activity to docetaxel both at early (before BBB disruption) and at advanced stages, consistent with enhanced brain penetration. 
Compared with similar dose levels of docetaxel, cabazitaxel induced significantly greater tumor growth inhibition across six pediatric tumor models and more tumor regressions in five of the six models. Therapeutic synergism was observed between cisplatin and cabazitaxel, regardless of administration sequence.http://link.springer.com/article/10.1007/s00280-013-2214-x

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Cannabis Seeds how to tell Male and Female Grow Your Own

THE PENDULUM METHOD:

This tip was given to me over 40 years ago and I still use it to this day to determine the sex of my seeds before I plant.....some may pass it off as an old wives tale.....but for me personally I have a 95% success rate and I would like to pass it on to you all with the hope that it can give you the same success!
I believe in the old school way of growing ( I also plant by the moon) I am not into the scientific approach to anything....If something works Istick with it.
All you need is a piece of string and a weight....( I use a necklace) using the hand that you use for writing ....hold the string between your thumb and index finger so that the weight is about 4" above the seed....wait for a while.....and observe whether the weight swings side to side (male) or goes around in circles (female)....this method works for all living plants and beings and for most people ..... But I have come across a few people that it does not work for.
For those that would be interested in giving it a go....I would love to hear how it went 

Pendulums have been around for thousands of years. The ancient Chinese used the pendulum principle to try and help predict earthquakes.
Galileo Galilei was the first European to really study pendulums and he discovered that their regularity could be used for keeping time, leading to the first clocks
In 1656, the Dutch inventor and mathematician, Huygens, was the first man to successfully build an accurate clock.

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Heavens 2 Betsey Compassionate Collective: www.heavens2betsey.com

International Cannabinoid Research Society:
www.cannabinoidsociety.org

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We have exposed the Bio-weapon cancer to the world.  Now we need to understand Cancer further.  If we can define cancer we can find the answers.


The.Kings.Cross.Sting...Research.Centre
http://www.dailytelegraph.com.au/news/nsw/ghost-sydney-rachel-forster-hospital-in-redfern-abandoned-in-2000-but-still-home-to-past/story-fni0cx12-1227167034141 The.Kings.Cross.Sting.... Cannabis.Clinic. Cancer.Research. Pool.for.healing.mediation.